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IL8 — MPL

Text-mined interactions from Literome

Mouithys-Mickalad et al., Biochem Biophys Res Commun 2004 : HCT and MPL inhibited the production of the cytokines TNFalpha and IL-8
Sohn et al., Chest 2005 (Pneumonia) : An examination was carried out into the effect of M pneumoniae lysate (MPL) and the role of mitogen activated protein kinases ( MAPKs ) and extracellular signal regulated kinase ( ERK ) on IL-8 expression in human lung epithelial cells ... In A549 cells, MPL induced IL-8 release in a time- and dose dependent manner ... Pretreatment with PD 98059, which blocks the activation of MAPK/ERK kinase 1, inhibited MPL induced IL-8 production by 64.4 % at 25 micromol/L. Stimulation of A549 cells by MPL also caused an increase in the activity of ERK, compared with the nonstimulated cells
Lee et al., J Clin Immunol 2013 (MAP Kinase Signaling System) : These results indicate that MPL induced IL-8 increase is transcriptionally regulated by NF-IL6 more than by NF-?B