We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK1

MAPK1 — PTHLH

Text-mined interactions from Literome

Miao et al., J Biol Chem 2001 (MAP Kinase Signaling System) : PTHrP increased mitogen activated protein kinase ( MAPK ) activity in BMC and MAPK activity, and PTHrP induced osteogenic cell proliferation could be blocked by the MEK inhibitor PD-098059 ... Although wortmannin and H8, inhibitors of phosphoinositol 3-kinase and protein kinase A, respectively, did not block PTHrP stimulated Ras or MAPK activity, chelerythrin chloride, a known protein kinase C inhibitor, did block these PTHrP actions as well as PTHrP induced osteogenic cell proliferation
Chan et al., Endocrinology 2001 : These results indicate that PTHrP can increase MAPK activity in 3T3-L1 cells via the PKA pathway, thereby enhancing PPAR gamma phosphorylation
Chen et al., J Biol Chem 2004 (MAP Kinase Signaling System) : PTHrP mediated down-regulation of PTH-1R mRNA and up-regulation of c-fos mRNA were MAPK independent, whereas PTHrP stimulation of fra-2 and interleukin-6 (IL-6) mRNA was MAPK dependent
Ortega et al., Clin Sci (Lond) 2007 (Myocardial Infarction) : Moreover, 10 ( -7 ) mol/l PTHrP- ( 1-36 ) increased ( 2-fold over control ) MAPK activation in human platelets