◀ Back to E2F1
E2F1 — SIRT1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
E2F1
→
SIRT1
(directlyDecreases, SIRT1 Activity, E2F1 Activity)
Wang et al., Nat Cell Biol 2006
Evidence: SirT1 binds to E2F1 and inhibits E2F1 activities, forming a negative feedback loop.
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NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
SIRT1 (SIRT1)
(transcription, activates)
Wang et al., Nat Cell Biol 2006, Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
SIRT1 (SIRT1)
(transcription, activates)
Wang et al., Nat Cell Biol 2006, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
SIRT1 (SIRT1)
→
E2F1 (E2F1)
(transcription, inhibits)
Wang et al., Nat Cell Biol 2006, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Nat Cell Biol 2006
:
This report shows that the cell-cycle and apoptosis regulator
E2F1 induces
SirT1 expression at the transcriptional level ... Furthermore,
SirT1 binds to E2F1 and
inhibits E2F1 activities, forming a negative feedback loop ... DNA damage by etoposide causes
E2F1 dependent induction of
SirT1 expression and knockdown of SirT1 increases sensitivity to etoposide
Pediconi et al., Mol Cell Biol 2009
:
The NAD ( + ) -dependent histone deacetylase
hSirT1 regulates cell survival and stress responses by inhibiting p53-, NF-kappaB-, and
E2F1 dependent transcription