Gene interactions and pathways from curated databases and text-mining

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CDH12 — NOTCH4

Text-mined interactions from Literome

Raymond et al., BMC developmental biology 2006 : Müller glia in the teleost retina have a complex response to local injury that includes some features of reactive gliosis ( up-regulation of glial fibrillary acidic protein, GFAP, and re-entry into the cell cycle ) together with dedifferentiation and re-acquisition of phenotypic and molecular characteristics of multipotent retinal progenitors in the CMZ ( diffuse distribution of N-cadherin , activation of Notch-Delta signaling, and expression of rx1, vsx2/Chx10, and pax6a ) along with characteristics associated with radial glia ( expression of brain lipid binding protein, BLBP )
Leong et al., J Exp Med 2007 (Breast Neoplasms) : Slug was essential for Notch mediated repression of E-cadherin , which resulted in beta-catenin activation and resistance to anoikis
Guichard et al., Nature 2010 : In human endothelial cells, the two toxins act in a conserved fashion to block formation of Sec15 vesicles, inhibit Notch signalling, and reduce cadherin expression at adherens junctions