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Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols
Park et al., Cytokine 2000 : Using a T cell clone ( 2D6 ) capable of responding to IL-2 and IL-12, we compared the effects of NAC on IL-2 and IL-12-driven T cell proliferation
Yamagishi et al., Med Chem 2006 : PEDF or NAC suppressed gene expression of interleukin-2 (IL-2) in Ang II-exposed MOLT-3 T cells
Wang et al., Food Chem Toxicol 2007 : The ANE mediated cytotoxicity, and suppression of IFN-gamma and IL-2 production were attenuated by the presence of antioxidant N-acetyl-l-cysteine (NAC)
Abdel Baki et al., PloS one 2010 (Brain Injuries) : When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Ren et al., PloS one 2012 : N-acetylcysteine (NAC) , a pharmacological antioxidant, increased T-cell proliferation and IL-2 production by TCR and ConA stimulated splenocytes but had no effect on the response to PHA in primary porcine splenocytes confirming that PHA induced T-cell activation is insensitive to the redox status
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012 : To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions
Jeannin et al., J Exp Med 1995 : In contrast, NAC and GSH had no effect on interferon gamma and increased IL-2 production and T cell proliferation
Eylar et al., Int Immunol 1993 : IL-2 secreted by T cells was also enhanced by NAC , approximately 1.5-fold, but IL-2 secreted by cells from old donors was enhanced by 3-fold