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CAV1 — TP53
Text-mined interactions from Literome
Ding et al., Jpn J Cancer Res 1999
(Adenocarcinoma...) :
In addition,
CAV induces the expression of
p53 and subsequent expression of a cyclin dependent kinase inhibitor, p21/WAF1
Ravid et al., Oncogene 2005
(Breast Neoplasms) :
Caveolin-1 inhibits cell detachment induced
p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling
Shajahan et al., J Biol Chem 2007
(Breast Neoplasms...) :
Furthermore, expression of p21, which correlates with taxane sensitivity, is regulated by
CAV1 phosphorylation in a
p53 dependent manner
Linge et al., Int J Biochem Cell Biol 2007
(Adenocarcinoma...) :
As predicted, we find that caveolin-1 amount increases in response to bleomycin-treatment and that modulation of
caveolin-1 affects p21 and
p53 levels, cell cycling, and senescence ( SA-beta-galactosidase activity )
Lin et al., J Virol 2010
(HIV Infections) :
The activity of
p53 is
essential for Tat induced
Cav-1 expression, as our findings show enhanced phosphorylation of serine residues at amino acid positions 15 and 46 in the presence of Tat with a resulting Cav-1 upregulation