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EGF — TH
Text-mined interactions from Literome
Futamura et al., Mol Psychiatry 2003
:
EGF-treatment induced transient impairment in
tyrosine hydroxylase expression
Halegoua et al., Cell 1980
(Pheochromocytoma) :
EGF but not insulin
enhances the phosphorylation of
tyrosine hydroxylase
Anastasiadis et al., Brain Res 1996
:
Regulation of
tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF,
EGF and IFN-gamma ... Rp-cAMP, an inhibitor of cAMP mediated responses, blocked the
induction of
tyrosine hydroxylase by NGF or
EGF ; inhibition of protein kinase C partially blocked the EGF effect, but not the NGF effect, NGF also induced GTP cyclohydrolase in a cAMP dependent manner, while the EGF effect was not blocked by Rp-cAMP or protein kinase C inhibitors ... Our results suggest that both
tyrosine hydroxylase and GTP cyclohydrolase are
induced in a coordinate and transcription dependent manner by NGF and
EGF , while conditions exist where the induction of tyrosine hydroxylase and GTP cyclohydrolase is not coordinately regulated