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SPP1 — TLR4

Text-mined interactions from Literome

Samuvel et al., J Biol Chem 2010 : Moreover, lipopolysaccharide or palmitic acid induced TLR4 activation and high glucose further augmented the coculture stimulated osteopontin secretion
Salvi et al., J Leukoc Biol 2013 : Dual regulation of osteopontin production by TLR stimulation in dendritic cells ... Here, we report that the activation of the MyD88 pathway by TLR2, TLR5 , and TLR7/8 agonists or IL-1ß induces high levels of OPN in human DCs ... These results highlight the biological relevance of the differential OPN induction by TLR2 and TLR4 agonists and emphasize the importance of TLR cross-talk in OPN induction ... This implies that OPN regulation by TLR signaling is critical in shaping inflammatory responses and may modulate IL-17 production in response to pathogens