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CDKN1A — KLF5
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2000
:
The gut enriched
Kruppel-like factor ( Kruppel-like factor 4 )
mediates the transactivating effect of p53 on the
p21WAF1/Cip1 promoter
Wu et al., Oncogene 2004
:
In addition,
KLF2 upregulates
p21WAF1/CIP1 expression
Yang et al., Cancer Biol Ther 2005
(Esophageal Neoplasms...) :
Both KLF4 and KLF5 upregulate the cdk inhibitor
p21 ( waf1/cip1 ) following UV irradiation, but the pro-apoptotic protein BAX is markedly
induced only by
KLF5
He et al., J Biochem 2009
(MAP Kinase Signaling System) :
Here, we show that Ang II upregulated
KLF5 and c-Jun expression and
inhibited p21 expression in VSMCs, and silencing of KLF5 expression by KLF5-specific small interfering RNA ( siRNA ) neutralized the inhibitory effects of Ang II on p21 expression
Song et al., Biochem Biophys Res Commun 2012
(Papilloma) :
Furthermore,
KLF10 dose-dependently
activated p21 ( WAF1/CIP1 ) transcription, which was independent of p53 and Sp1 binding sites in p21 ( WAF1/CIP1 ) promoter