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MAPK1 — SOCS3
Text-mined interactions from Literome
Bode et al., Biol Chem 2001
(Carcinoma, Hepatocellular) :
We analyzed the
role of
MKK6/p38MAPK for IL-6 signal transduction and transcriptional activation of the suppressor of cytokine signaling
(SOCS) 3 promoter
Jegalian et al., J Interferon Cytokine Res 2002
:
Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of SOCS1, SOCS2,
SOCS3 , and cytokine-inducible SH2 containing protein ( CIS ) in response to EPO stimulation appears to
depend on Stat5 but not on
mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Zvonic et al., J Biol Chem 2004
:
The effects of CT-1 on
SOCS-3 and PPARgamma mRNA were
independent of
MAPK activation
Qin et al., J Immunol 2007
(MAP Kinase Signaling System) :
These results indicate that LPS induced
MAPK activation, the production of endogenous IL-10, and STAT-3 activation
play critical roles in
SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Puhr et al., Endocr Relat Cancer 2010
(Carcinoma...) :
Decreased
SOCS-3 protein expression
results in increased
MAPK phosphorylation, whereas SOCS-3 overexpression leads to a decreased cellular proliferation and migration