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CASP14 — TOP1
Text-mined interactions from Literome
Sordet et al., J Biol Chem 2004
(Leukemia) :
The
caspase inhibitor, benzyloxycarbonyl-VAD partially
prevents arsenic trioxide induced
topoisomerase I-DNA complexes and apoptosis, suggesting that activated caspases further maintain intracellular levels of reactive oxygen species that induce the formation of topoisomerase I-DNA complexes
Sheets et al., Infect Immun 2005
:
Apoptosis associated events, including annexin V positivity,
caspase-3 activation , and cleavage of the caspase substrates poly ( ADP-ribose ) polymerase and
topoisomerase I (Topo I) , were observed in endothelial cells after detachment
Kelner et al., Invest New Drugs 2008
(Lung Neoplasms) :
The synergistic interaction with these combinations may stem from a variety of actions including inhibition of the nucleotide excision repair ( NER ) pathway,
topoisomerase I activity, and
caspase dependent and independent
induction of apoptosis
Sordet et al., J Biol Chem 2008
:
Those apoptotic
Top1cc are
prevented by
caspase inhibition and Bax inactivation, indicating that both caspases and the mitochondrial death pathway are required for their formation