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MAPK14 — PTPN11
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mañes et al., Mol Cell Biol 1999
(Neoplasm Invasiveness) :
Although
SHP-2 regulates
mitogen activated protein kinase activity, the mitogen activated protein kinase kinase inhibitor PD-98059 has only a marginal effect on MCF-7 cell migration
Oh et al., Mol Cell Biol 1999
:
Overexpression of SHPS-1 in 293 cells potentiated integrin induced
mitogen activated protein kinase ( MAPK ) activation, and potentiation
required functional
SHP-2
O'Reilly et al., Mol Cell Biol 2000
:
Previously, using a dominant negative mutant approach, we showed that the protein-tyrosine phosphatase
SHP-2 is
necessary for FGF induced
MAPK activation, mesoderm induction, and elongation of animal caps
Inagaki et al., Oncogene 2000
:
SHP-2 , a SRC homology 2 domain containing protein tyrosine phosphatase,
mediates activation of Ras and
mitogen activated protein kinase by various mitogens and cell adhesion
Cunnick et al., J Biol Chem 2001
:
Thus, physical association of activated
SHP2 with Gab1 is necessary and
sufficient to mediate the ERK
mitogen activated protein kinase activation
Kontaridis et al., J Cell Sci 2001
:
Inhibition of p38
MAPK by SB203580 in differentiating C2C12 myoblasts
blocks MyoD expression, SHPS-1 tyrosyl phosphorylation and the association of SHPS-1 with
SHP-2
Cai et al., J Cell Biol 2002
(MAP Kinase Signaling System) :
Gab1 and
SHP-2 promote
Ras/MAPK regulation of epidermal growth and differentiation
Lundin Brockdorff et al., Cytokine 2002
(MAP Kinase Signaling System...) :
SHP2 regulates IL-2 induced
MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells ... The cells transfected with inactive SHP2 showed reduced MAPK activation upon IL-2 stimulation, suggesting that
SHP2 upregulates IL-2 induced
MAPK activation in T cells ... In conclusion, we show for the first time that
SHP2 positively
regulates IL-2 induced
MAPK activation in malignant T cells
Zhan et al., Cancer Res 2004
(Brain Neoplasms...) :
SHP-2 dependent
mitogen activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival
Easton et al., J Neurochem 2006
(Neuroblastoma) :
Shp2 is required for complete MAPK activation by BDNF, as expression of a dominant negative
Shp2 in cells
attenuates BDNF induced activation of
MAPK
Howlett et al., Biochim Biophys Acta 2009
(Helicobacter Infections...) :
It has been established that blockade of
SHP2 activation of
MAPK signalling results in hyperactivation of STAT3 resulting in increased cell proliferation, angiogenesis, inflammation and inhibition of both immunocyte and epithelial cell apoptosis
Chen et al., J Cell Biochem 2010
(Inflammation) :
These findings highlight a novel negative regulatory role for integrin beta4 in EC inflammatory responses involving
SHP-2 mediated
MAPK signaling
Tartaglia et al., Molecular syndromology 2010
:
SHP2 ( encoded by PTPN11 ), SOS1, BRAF, RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Cascino et al., Antioxid Redox Signal 2011
(Disease Models, Animal...) :
These findings provide the first evidence that adventitia derived H ( 2 ) O ( 2 ) participates in vascular dysfunction through p38
MAPK activation and
SHP-2 inhibition
Fang et al., PloS one 2012
:
Signaling regulatory mechanism investigation using immunoblotting, immunoprecipitation, and GST pull-down assay reveals that the down-regulation of
Shp2 expression in RBL cells
leads to decreased activities of Fyn, PLC?, JNK,
p38MAPK , and Ras/Erk1/2 after FceR? aggregation
Li et al., J Immunol 2012
(Acute Disease...) :
In vitro biochemical data correlate CSE mediated IL-8 release with
Shp2 regulated epidermal growth factor receptor/Grb-2 associated
binders/MAPK signaling
Zhao et al., J Biol Chem 1995
:
Altered expression of
protein-tyrosine phosphatase 2C in 293 cells
affects protein tyrosine phosphorylation and
mitogen activated protein kinase activation ... Overexpression of the native
PTP2C enhanced epidermal growth factor (EGF) stimulated
mitogen activated protein ( MAP ) kinase activity by 30 %, whereas expression of the inactive mutant reduced the stimulated activity by 50 %
Bennett et al., Mol Cell Biol 1996
:
Overexpression of catalytically inactive
SHPTP2 ( PTP2CS ) but not catalytically inactive SHPTP1,
inhibited mitogen activated protein ( MAP ) kinase activation and Elk-1 transactivation following epidermal growth factor (EGF) stimulation of 293 cells
Tsuda et al., J Biol Chem 1998
:
Overexpression of a catalytically inactive
SHP-2 markedly
inhibited activation of
mitogen activated protein ( MAP ) kinase in response to fibronectin stimulation without affecting the extent of tyrosine phosphorylation of focal adhesion kinase or its interaction with the docking protein Grb2
Deb et al., J Biol Chem 1998
:
In this report we studied the
role of protein-tyrosine phosphatase
SHP-2 in ErbB mediated activation of
mitogen activated protein kinase ( MAPK ) by overexpressing SHP-2 mutants in COS-7 cells
Myers et al., J Biol Chem 1998
:
Although several reports suggest a critical role for
SHP-2 in insulin
stimulated mitogen activated protein kinase activation and cell proliferation, IRS-1 ( FCT ) mediated these effects normally in 32D cells