Lovren et al., Am J Physiol Endocrinol Metab 2009
(Atherosclerosis...) :
Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo : translational implications for atherosclerosis ... Visfatin increased total Akt and Ser ( 473 ) -phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser ( 1177 ) ; these effects were blocked by LY-2940002 ... Visfatin also activated mitogen activated protein ( MAP ) kinase through PI 3-kinase, and mitogen/extracellular signal regulated kinase inhibition attenuated visfatin elicited Akt and eNOS phosphorylation
Yamawaki et al., Biochem Biophys Res Commun 2009
:
Visfatin ( 100 ng/ml, 20 min ) induced a phosphorylation of eNOS at serine 1177 and a de-phosphorylation of eNOS at threonine 495
Kang et al., J Pineal Res 2013
:
Melatonin inhibits visfatin induced inducible nitric oxide synthase expression and nitric oxide production in macrophages