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LEP — UCP1

Text-mined interactions from Literome

Commins et al., Endocrinology 1999 (Body Weight...) : Leptin also increases uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT), but the neurotransmitter that mediates this effect has not been established ... The present experiments sought to determine whether leptin regulates UCP1 expression in BAT and its own expression in white adipose tissue ( WAT ) through the long or short forms of leptin receptor and modulation of norepinephrine release ... Leptin produced a 4-fold increase in UCP1 mRNA levels in Dbh+/- mice but had no effect on UCP1 expression in Dbh-/-
Kumar et al., Pflugers Arch 1999 : In young rats, CL316,243 infusion reduced body mass and adiposity, suppressed serum leptin and leptin mRNA levels in WAT, induced UCP1 in WAT, and increased UCP1 and LPL mRNA levels in BAT
Rohner-Jeanrenaud et al., International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000 (Weight Gain) : Leptin increases the expression of uncoupling proteins ( UCP-1 , -2, -3 ) and thus energy dissipation
Al-Barazanji et al., Diabetes Obes Metab 2001 (Obesity...) : Both m-leptin and h-leptin i.c.v. infusion reduced body weight gain ( 3 % and 4 %, respectively, compared to pair fed group ) and increased UCP-1 expression ( 11-fold and 16-fold, respectively ) in lean rats
Cettour-Rose et al., Am J Physiol Endocrinol Metab 2002 : The additional observation of a leptin induced increased mRNA expression of BAT uncoupling protein-1 suggested that the effect on BAT D2 may be mediated by the sympathetic nervous system
Masaki et al., Endocrinology 2003 : In peripheral tissue, leptin up-regulated BAT UCP1 mRNA expression and reduced fat depositions in this tissue
Wilsey et al., Am J Physiol Regul Integr Comp Physiol 2003 (Body Weight...) : rAAV-leptin caused an increase in STAT3 phosphorylation and proopiomelanocortin expression in the hypothalamus and an increase in uncoupling protein-1 in brown adipose tissue in both Chow and DR animals, but failed to do so in DIO
Xiao et al., Endocrinology 2004 (Body Weight) : The present results suggest that the inhibition of leptin secretion during lactation is involved in the down-regulation of UCP expression in BAT and skeletal muscle, which, in turn, is responsible for the decrease in metabolic fuel oxidation and thermogenesis
Wilsey et al., Endocrinology 2006 (Weight Gain) : V also augmented the leptin induced increase in brown adipose tissue uncoupling protein-1
Zhang et al., Am J Physiol Regul Integr Comp Physiol 2007 (Body Weight) : We hypothesized that leptin is necessary for homeostatic restoration of the HF-enhanced caloric intake and may mediate the increase in uncoupling protein-1 (UCP1) in brown adipose tissue (BAT)
Asensio et al., Int J Obes Relat Metab Disord 2008 : Leptin increased UCP1 and D2 mRNA levels in WT mouse BAT 1.7- and 3-fold, respectively, but had no effect on the expression of these genes in beta-less mouse BAT ... The stimulatory effects of leptin on oxygen consumption, BAT UCP1 and D2 expression require functional beta-adrenoceptors, but its inhibitory effect on food intake and its stimulatory effect on fat utilization is independent of the beta-adrenoceptor signalling
Yoshimatsu et al., Nutrition 2008 (Body Weight...) : Leptin induced suppression of food intake and upregulation of uncoupling protein-1 expression in brown adipose tissue were partially attenuated in histamine H(1)-R knockout ( H ( 1 ) KO ) mice
Okamatsu-Ogura et al., Experimental biology and medicine (Maywood, N.J.) 2011 : As chronic leptin stimulation induces UCP1 expression in BAT and ectopically in white adipose tissue ( WAT ), we mimicked the UCP1 induction by repeated injection of CL316,243 ( CL ), a highly specific ß3-adrenoceptor agonist, and measured food intake in response to a single injection of leptin
Scarpace et al., Am J Physiol 1997 (Obesity) : Leptin increased BAT UCP mRNA levels greater than twofold in both ad libitum fed and food restricted rats
Satoh et al., Neurosci Lett 1998 (Body Weight) : Co-injection of SHU9119 also inhibited completely the leptin induced increase in UCP-1 mRNA expression in the BAT
Scarpace et al., Am J Physiol 1998 : Leptin induction of UCP1 gene expression is dependent on sympathetic innervation ... These data indicate that the leptin induction of UCP1 gene expression in BAT is dependent on sympathetic innervation but that the leptin induction of LPL gene expression is not
Kotz et al., Am J Physiol 1998 : Next, we determined that leptin decreases NPY and increases UCP gene expression
Mizuno et al., Endocrinology 1998 (Hypoglycemia) : In intact rats infused with leptin ( 0.31 micromol/day ), the expression of uncoupling protein-1 messenger RNA in interscapular brown adipose tissue was increased, whereas no such effect of leptin on the uncoupling protein-1 messenger RNA expression was observed in brown adipose tissue in chemically sympathectomized rats
Arvaniti et al., Endocrinology 1998 (Obesity) : Corticosterone increased food intake and reduced the expression of IBAT UCP1 regardless of the leptin status, and leptin reduced food intake and induced the expression of IBAT UCP1 independently of the corticosterone levels