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GRB10 — IGF2

Text-mined interactions from Literome

Wang et al., Mol Cell Biol 1999 : ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I , and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion
Morrione et al., J Cell Physiol 2003 : Many recent reports have suggested a very important role of Grb10 in regulating IGF-IR signaling ... In this review, we will focus on the role of Grb10 in IGF-I induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand induced ubiquitination, internalization, and stability of the IGF-IR
Monami et al., J Cell Physiol 2008 : We have shown that Grb10 binds the E3 ubiquitin ligase Nedd4 and promotes IGF-I stimulated ubiquitination, internalization, and degradation of the IGF-IR , thereby giving rise to long-term attenuation of signaling