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CASP12 — NOS1
Text-mined interactions from Literome
Nakagawa et al., J Cell Biochem 2005
:
TNF-alpha induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor ( 10 ( -8 ) M ), while LPS- or Bay K 8644 induced decrease in cell number was significantly prevented by
caspase-3 inhibitor or N omega-nitro-L-arginine methylester ( NAME ) ( 10 ( -5 ) M ), an
inhibitor of
nitric oxide ( NO ) synthase
Gupta et al., J Am Soc Nephrol 2007
(Acute Kidney Injury...) :
Treatment of septic animals with APC reduced blood urea nitrogen, renal pathology, and chemokine expression and dramatically reduced the induction of inducible
nitric oxide synthase and
caspase-3 activation in the kidney
Chuang et al., Neuropharmacology 2007
(Epilepsy, Temporal Lobe...) :
In Sprague-Dawley rats, significant and temporally correlated upregulation of NOS II ( 3-24h ), but not
NOS I or II expression, enhanced cytosolic translocation of cytochrome c ( days 1 and 3 ),
augmented activated
caspase-3 in cytosol ( days 1, 3 and 7 ) and DNA fragmentation ( days 1, 3 and 7 ) was detected bilaterally in the hippocampal CA3 subfield after elicitation of sustained seizure activity by microinjection of kainic acid into the unilateral CA3 subfield
Braun et al., Int J Neurosci 2009
(Disease Models, Animal...) :
Inducible
nitric oxide synthase mediates hippocampal
caspase-3 activation in pneumococcal meningitis
Adamczyk et al., FEBS Lett 2010
:
The inhibitor of Ca2+ dependent
NOS ( N-nitro-L-arginine, 100 microM )
prevented ASN evoked
caspase-3 activation and PARP-1 degradation
Chernigovskaya et al., Biotech Histochem 2011
:
Thus, we demonstrated that gene disruption of
nNOS prevents activation of Bcl-2, p53 and
caspase-9 expression during water deprivation, and that nNOS deficiency did not affect survival of magnocellular neurons of the hypothalamus
D'Agostino et al., Biol Psychiatry 2012
(Alzheimer Disease...) :
According with the neuroprotective profile of PEA observed during behavioral studies, experimental molecular and biochemical markers induced by Ab25-35 injection, such as lipid peroxidation, protein nytrosylation, inducible
nitric oxide synthase induction , and
caspase3 activation, were reduced by PEA treatment
Wang et al., Brain Res Bull 2012
(Hypoxia-Ischemia, Brain) :
In the meanwhile, the microbubbles attenuated the production of inducible
nitric oxide synthase , nitric oxide and tumor necrosis factor-alpha, as well as the
activation of
caspase-3 in insulted side of brain in neonatal rats
Zhou et al., Am J Physiol Heart Circ Physiol 2013
:
Inhibition of
NOS prevented H ( 2 ) O ( 2 ) -induced
caspase activation, cell apoptosis, and increases in endothelial [ Ca ( 2+ ) ] ( i ) and Lp
Yang et al., Int Immunopharmacol 2013
:
Inhibition of
NOS could
block the activation of
caspase-9 , but had no obvious effect on cell apoptosis
Bai et al., Vet Immunol Immunopathol 2013
:
Besides, apoptotic rates increase and
caspase-3 activation were
suppressed by
NOS inhibitor or antioxidant