◀ Back to MAPK8
MAPK8 — MITF
Text-mined interactions from Literome
Ahn et al., Arch Dermatol Res 2008
(MAP Kinase Signaling System) :
Furthermore, p38 MAPK functionally regulated the LPS induced melanin formation in melanocytes ; a p38
MAPK inhibitor, SB203580, almost completely
attenuated the LPS mediated up-regulation of melanin synthesis and induction of
MITF and tyrosinase expression
Jiang et al., Life Sci 2009
(Melanoma, Experimental) :
Furthermore, Western blot analysis revealed that THSG elevated the level of phosphorylation of p38 mitogen activated protein kinase ( p38 MAPK ) significantly at 1-6 h ; a p38
MAPK inhibitor, SB203580, almost completely
attenuated the THSG mediated up-regulation of melanin synthesis and induction of
MITF and tyrosinase expression
Park et al., International journal of cell biology 2009
:
Then the activated
MAPK/ERK caused an acute phosphorylation of
MITF , followed by proteosome mediated degradation of MITF, the key transcription factor for melanogenic proteins [ Wu et al. ( 2000 ) Gene & Development : 14 ]
Wu et al., J Biomed Sci 2011
(Hyperpigmentation...) :
Cpc exerted dual antimelanogenic mechanisms by upregulation of
MAPK/ERK dependent degradation of
MITF and downregulation of p38 MAPK regulated CREB activation to modulate melanin formation
Zhou et al., J Ethnopharmacol 2012
(Melanoma, Experimental) :
The special p38
MAPK inhibitor, SB203580, and protein kinase A (PKA) inhibitor, H89, both
attenuated the AVE induced up-regulation of
MITF and tyrosinase expression in B16F10 cells and NHMC ... AVE exerts its improving effect on melanogenesis mainly by p38
MAPK activation and
MITF induction of tyrosinase