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MAP3K2 — MAPK9
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK9
→
MAP3K2
(directlyIncreases, MAP3K2 Activity, MAPK9 Activity)
Evidence: Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.
Text-mined interactions from Literome
Kesavan et al., J Cell Physiol 2004
:
The purpose of this study was to define the specific
role of
MEKK2 , an MKKK, in
MAPK regulation and cell function
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)