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IL22 — IRF4
Text-mined interactions from Literome
Mudter et al., Inflamm Bowel Dis 2011
(Colitis...) :
In contrast to DSS colitis,
IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and
impaired IL-6, IL-17a, and
IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Valdez et al., Immunity 2012
(Cryptococcosis) :
We show that
IRF4 was required for IL-17 expression but
inhibited IL-22 expression, highlighting the potential for discordant regulation of these two cytokines in Th17 cells
Raifer et al., Eur J Immunol 2012
(Encephalomyelitis, Autoimmune, Experimental) :
Unlike aß T cells, ?d T cells, LTi cells and NKT cells do not
require IRF4 for the production of IL-17A and
IL-22