Moore et al., J Clin Endocrinol Metab 1999
(Acromegaly) :
Neither IGF-I nor GH had any effect on 11betaHSD2 activity
Tomlinson et al., Endocr Res 2000
(Obesity...) :
IGF-1 caused a dose dependant inhibition of 11beta-HSD1 activity in both subcutaneous and omental stromal cells
Stewart et al., Horm Res 2001
(Hypopituitarism...) :
As assessed by urinary free cortisol/urinary free cortisone ratios and endorsed through in vitro studies, neither GH nor insulin-like growth factor (IGF)-I affect 11beta-HSD2 activity ... These clinical data suggest that GH ( and/or IGF-I ) inhibits 11beta-HSD1 ( i.e. E to F conversion ) ( parallel in vitro studies suggest that IGF-I and not GH inhibits 11beta-HSD1 )
Morita et al., Endocr J 2009
:
In the present study, we investigated the effects of GH or IGF-I on the activity of 11beta- HSD1 in 3T3-L1 cell homogenates and its mRNA expression ... In conclusion, 11beta-HSD1 activity was suppressed by GH or IGF-I in differentiated adipocytes, probably due to a reduction of 11beta-HSD1 mRNA levels