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ARHGEF25 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RhoA activity: GEFT (ARHGEF25) → RHOA/GTP complex (RHOA) (modification, activates) Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004*, Lutz et al., J Biol Chem 2005*, Lutz et al., Science 2007*, Swenson-Fields et al., Mol Cell 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RhoA activity: GEFT (ARHGEF25) → RHOA/GDP complex (RHOA) (modification, activates) Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004*, Lutz et al., J Biol Chem 2005*, Lutz et al., Science 2007*, Swenson-Fields et al., Mol Cell 2008*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — ARHGEF25 (direct interaction, enzymatic study) Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004*
• IRef Biogrid Interaction: RHOA — ARHGEF25 (direct interaction, pull down) Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004*
• MIPS CORUM GNAQ-GEFT-RHOA complex: GNAQ-GEFT-RHOA complex complex (ARHGEF25-GNAQ-RHOA) Lutz et al., Science 2007*
• IRef Corum Interaction: Complex of RHOA-ARHGEF25-GNAQ (association, x-ray crystallography) Lutz et al., Science 2007*
• IRef Hprd Interaction: RHOA — ARHGEF25 (in vitro) Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004*

Text-mined interactions from Literome

Souchet et al., J Cell Sci 2002 : In vitro guanine nucleotide exchange assays have shown that p63RhoGEF specifically acts on RhoA ... Moreover, we show that p63RhoGEF activation of RhoA in intact cells is dependent on the presence of the PH domain
Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004 (Urinary Bladder Neoplasms) : When expressed in human embryonic kidney cells, both p63RhoGEF and GEFT caused activation of RhoA , but not Rac1 or Cdc42, and induced serum response factor mediated gene transcription, which was fully blunted by the Rho inactivating C3 transferase
Lutz et al., J Biol Chem 2005 : We further demonstrate that active G alpha ( q ) or G alpha11, but not G alpha12 or G alpha13, strongly enhances p63RhoGEF induced RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half
Wuertz et al., FASEB J 2010 : The purpose of our study was to investigate the role of endogenous p63RhoGEF in G ( q/11 ) -dependent RhoA activation and signaling in rat aortic smooth muscle cells ( RASMCs )