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SRC — SRF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SRF → SRC (increases, SRC Activity, SRF Activity) Xu et al., J Biol Chem 2007*
  Evidence: XB130 expression in HEK293 cells enhanced serum response element- and AP-1-dependent transcriptional activation mediated by c-Src.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — SRF (direct interaction, two hybrid) Kim et al., J Biol Chem 1998*
• IRef Biogrid Interaction: SRC — SRF (direct interaction, pull down) Kim et al., J Biol Chem 1998*
• IRef Hprd Interaction: SRC — SRF (in vitro) Kim et al., J Biol Chem 1998*
• IRef Ophid Interaction: SRC — SRF (aggregation, confirmational text mining) Kim et al., J Biol Chem 1998*
• IRef Ophid Interaction: SRC — SRF (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Godeny et al., Am J Physiol Cell Physiol 2006 : A loss of c-Src/Yes/Fyn blocked ANG II-dependent RSK2 activation, RSK2 nuclear translocation, serum-response factor (SRF) phosphorylation, a portion of c-fos transcriptional activity and c-Fos phosphorylation
Mao et al., EMBO J 1998 : Furthermore, Src , which was previously shown to activate kinase activities of Tec kinases, activates SRF predominantly in Rho independent pathways in 3T3 cells, as shown by the fact that C3 did not block Src mediated SRF activation