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PRKCD — TGFB1

Text-mined interactions from Literome

Kucich et al., Arch Biochem Biophys 2000 : TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta , and p38, but not erk1/erk2
La Porta et al., Melanoma Res 2000 (Lung Neoplasms...) : Overexpression of nPKCdelta in BL6 murine melanoma cells enhances TGFbeta1 release into the plasma of metastasized animals ... On the other hand, higher levels of this cytokine, in particular in its active form, occur in the plasma of BL6T metastasized animals, suggesting a nPKCdelta dependent TGFbeta1 release ... Therefore, nPKCdelta dependent TGFbeta1 release and activation may be involved in the greater angiogenic and metastatic capacity of murine melanoma BL6T cells
Kucich et al., Am J Respir Cell Mol Biol 2002 : In the present work, using cultured human fetal lung fibroblasts, we show through the use of specific inhibitors and transfection of a Smad 7 construct that in addition to de novo protein synthesis and active Smads, the extended activity of protein kinase C (PKC)-delta and the stress activated protein kinase, p38, is required for TGF-beta1 to achieve elastin mRNA stabilization