Gene interactions and pathways from curated databases and text-mining

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EP300 — PRMT1

Pathways - manually collected, often from reviews:

  • NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) (transcription, activates)
    An et al., Cell 2004, Gamper et al., Mol Cell Biol 2008
    Evidence: mutant phenotype, reporter gene, physical interaction
  • NCI Pathway Database Direct p53 effectors: PRMT1 (PRMT1) → p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) (modification, collaborate)
    An et al., Cell 2004
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database Direct p53 effectors: PRMT1 (PRMT1) → nucleus (EP300/CREBBP) (modification, collaborate) An et al., Cell 2004
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → nucleus (EP300/CREBBP) (modification, collaborate) An et al., Cell 2004
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → CARM1 (CARM1) (modification, collaborate) An et al., Cell 2004
    Evidence: mutant phenotype, physical interaction
  • NCI Pathway Database Direct p53 effectors: p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) → p53 (tetramer) complex (TP53) (modification, collaborate)
    An et al., Cell 2004
    Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *