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PARP1 — SOX2
Text-mined interactions from Literome
Gao et al., J Biol Chem 2009
:
When
PARP1 activity is inhibited or absent, poly ( ADP-ribosyl ) ation of Sox2 decreases and association of
Sox2 with FGF4 enhancers
increases , accompanied by an elevated level of Sox2 proteins and reduced expression of FGF4
Lai et al., Proc Natl Acad Sci U S A 2012
:
The results presented below demonstrate that
Parp1 regulates
Sox2 protein activity ... In response to fibroblast growth factor ( FGF ) /extracellular signal regulated kinase ( ERK ) signaling, Parp1 auto-poly ADP-ribosylation enhances
Sox2-Parp1 interactions, and this complex
inhibits Sox2 binding to octamer binding transcription factor 4 ( Oct4 ) /Sox2 enhancers ... In addition, we demonstrate that
regulation of
Sox2 activity by
Parp1 is critical for efficient generation of induced pluripotent stem cells