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AXIN1 — LRP5

Pathways - manually collected, often from reviews:

• NCI Pathway Database N-cadherin signaling events: LRP5 (LRP5) → Axin1 (AXIN1) (modification, collaborate) Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: LRP5 (LRP5) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: Axin1 (AXIN1) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• Reactome Reaction: AXIN1 → LRP5 (reaction) Tamai et al., Mol Cell 2004, He et al., Development 2004, Zeng et al., Nature 2005, MacDonald et al., J Biol Chem 2008
• Reactome Reaction: AXIN1 → LRP5 (indirect_complex) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Davidson et al., Nature 2005, Zeng et al., Nature 2005, Bilic et al., Science 2007, MacDonald et al., J Biol Chem 2008

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LRP5 — AXIN1 (physical association, affinity chromatography technology) Ding et al., J Cell Biol 2008
• IRef Biogrid Interaction: LRP5 — AXIN1 (physical association, affinity chromatography technology) Mao et al., Mol Cell 2001
• IRef Biogrid Interaction: LRP5 — AXIN1 (physical association, affinity chromatography technology) Kim et al., FASEB J 2008*
• IRef Hprd Interaction: LRP5 — AXIN1 (in vivo) Mao et al., Mol Cell 2001
• IRef Ophid Interaction: LRP5 — AXIN1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: LRP5 — AXIN1 (interaction, mapped from kegg_pathways)
• STRING interaction: AXIN1 — LRP5 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Tolwinski et al., Dev Cell 2003 : We propose that Arrow ( LRP ) recruits Axin to the membrane, and that this interaction leads to Axin degradation
Cadigan et al., J Cell Sci 2006 : These involve activation of Dishevelled ( Dsh ), possibly through trimeric G proteins and LRP mediated axin binding and/or degradation