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CALM2 — GAD1
Text-mined interactions from Literome
Benson et al., J Neurosci 1991
:
Increases in immunocytochemically detectable type II
calcium-calmodulin dependent protein kinase ( CaM II kinase ) and decreases in immunocytochemically detectable
glutamic acid decarboxylase (GAD) are known to occur in the visual cortex of adult monkeys following brief periods of monocular visual deprivation
Ludewig et al., PloS one 2008
:
In plants, the pathway is composed of the
calcium/calmodulin regulated cytosolic enzyme
glutamate decarboxylase (GAD) , the mitochondrial enzymes GABA transaminase ( GABA-T ; POP2 ) and succinic semialdehyde dehydrogenase ( SSADH )
Gut et al., J Mol Biol 2009
:
We determined the crystal structure of Arabidopsis thaliana Gad1 in its CaM-free state, obtained a low-resolution structure of the
calmodulin activated
Gad complex by small-angle X-ray scattering and identified the crucial residues, in the C-terminal domain, for regulation by pH and CaM binding
Wang et al., J Sci Food Agric 2010
:
Our preliminary studies showed that rice bran GAD is probably also a Ca ( 2+ ) /CaM dependent enzyme ; hence, in the current investigation, we purified calmodulin from rice bran, and studied the
effect of the Ca ( 2+ )
/calmodulin complex on the activity of rice bran
GAD in vitro
Snedden et al., J Biol Chem 1996
:
Neither calcium nor
calmodulin alone
had any effect on
GAD activity ... Furthermore,
activation of
GAD by two different proteins that interact with the calmodulin binding domain, a monoclonal antibody or
calcium/calmodulin , suggests that this domain plays a major role in the regulation of plant GAD activity
Liang et al., Exp Brain Res 1996
:
Expression patterns of the immediate early gene c-fos and of other genes including those for the alpha-subunit of type II
Ca2+/calmodulin dependent protein kinase ( CaMKII alpha ),
67-kDa glutamic acid decarboxylase ( GAD ), and the alpha 1-, beta 2-, and gamma 2-subunits of the GABAA receptor were described in the spinal cord of normal cats and following peripheral nerve stimulation