◀ Back to PCNA
ANAPC4 — PCNA
Text-mined interactions from Literome
Zachariae et al., Curr Opin Cell Biol 1999
:
Progression through mitosis is controlled by
cyclin dependent kinases, which drive cells into metaphase, and by the
anaphase promoting complex/cyclosome , a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis
Tyson et al., J Theor Biol 2001
:
First, we present a simple model of the antagonistic interactions between
cyclin dependent kinases and the
anaphase promoting complex , which shows how progress through the cell cycle can be thought of as irreversible transitions ( Start and Finish ) between two stable states ( G1 and S-G2-M ) of the regulatory system
Irniger et al., FEBS Lett 2002
:
Cyclin proteolysis is
triggered by the
anaphase promoting complex/cyclosome ( APC/C ), a multi-subunit complex which contains ubiquitin ligase activity
Guardavaccaro et al., Dev Cell 2003
(Infertility, Male) :
Furthermore, cyclin A,
cyclin B, and Emi1, an
inhibitor of the
anaphase promoting complex , are stabilized in mitotic beta-Trcp1 ( -/- ) MEFs
Margottin-Goguet et al., Dev Cell 2003
:
Progression through mitosis occurs because
cyclin B/Cdc2 activation
induces the
anaphase promoting complex (APC) to cause cyclin B destruction and mitotic exit
Archambault et al., Expert Rev Proteomics 2005
:
In the past 5 years, developments in mass spectrometry based proteomics have been applied to the study of protein interactions and post-translational modifications involving key cell cycle regulators such as
cyclin dependent kinases and the
anaphase promoting complex , as well as effectors such as centrosomes, the kinetochore and DNA replication forks
Ban et al., Dev Cell 2007
:
Cyclin dependent kinase 1 (Cdk1) initiates mitosis and later
activates the
anaphase promoting complex/cyclosome ( APC/C ) to destroy cyclins
Kang et al., Hum Pathol 2009
(Breast Neoplasms...) :
Cyclin B proteolysis is
triggered by the
anaphase promoting complex
Wijnker et al., Plant reproduction 2013
:
Progression through meiosis relies on many of the same, or at least homologous, cell cycle regulators that act in mitosis, e.g.,
cyclin dependent kinases and the
anaphase promoting complex/cyclosome