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CREB5 — SIRT1
Text-mined interactions from Literome
Gao et al., Nature 2010
(Memory Disorders) :
SIRT1 normally functions to limit expression of miR-134 via a repressor complex containing the transcription factor YY1, and unchecked miR-134 expression following
SIRT1 deficiency
results in the downregulated expression of
CREB and brain derived neurotrophic factor (BDNF), thereby impairing synaptic plasticity
Noriega et al., EMBO Rep 2011
:
CREB and ChREBP oppositely
regulate SIRT1 expression in response to energy availability
Fusco et al., Proc Natl Acad Sci U S A 2012
:
Moreover,
CREB deficiency drastically
reduces the expression of
Sirt-1 and the induction of genes relevant to neuronal metabolism and survival in the cortex and hippocampus of dietary restricted animals ... Biochemical studies reveal a complex interplay between CREB and Sirt-1 :
CREB directly
regulates the transcription of the
sirtuin in neuronal cells by binding to Sirt-1 chromatin ; Sirt-1, in turn, is recruited by CREB to DNA and promotes CREB dependent expression of target gene peroxisome proliferator activated receptor-? coactivator-1a and neuronal NO Synthase
Monteserin-Garcia et al., FASEB J 2013
:
Therefore, the present study investigates how
Sirt1 affects
CREB function and GH synthesis ...
Sirt1 activation and overexpression
suppressed forskolin induced
CREB-Ser ( 133 ) phosphorylation, but no effect was seen with vehicle and empty plasmid controls