Gondi et al., Mol Cancer Ther 2006
(Glioma) :
RNA interference mediated simultaneous down-regulation of urokinase-type plasminogen activator receptor and cathepsin B induces caspase-8 mediated apoptosis in SNB19 human glioma cells
Kobayashi et al., J Biol Chem 1991
:
Cathepsin B efficiently activates the soluble and the tumor cell receptor bound form of the proenzyme urokinase-type plasminogen activator ( Pro-uPA )
Clavel et al., Ann Pathol 1988
(Breast Neoplasms...) :
Physicochemical properties of collagenases, ionic and cellular environment condition their activity which is also enzyme dependent ( activation by plasmin , cathepsin B ... ) Type IV collagenase activity is related to the invasive and metastatic ability of tumor cells