Gene interactions and pathways from curated databases and text-mining

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AKT1 — PRNP

Text-mined interactions from Literome

Liang et al., FEBS J 2009 (Stomach Neoplasms) : Inhibition of PrP ( C ) expression by RNA interference resulted in decreased p-Akt expression
Seo et al., J Neurochem 2010 (Anoxia...) : The results indicate that hypoxia protects neuronal cells against PrP ( 106-126 ) -induced cell death by activating the Akt signal, which is inactivated by prion proteins, and inhibiting PrP ( 106-126 ) -induced caspase 3 activation
Liu et al., PloS one 2013 : The activation of Akt then induces the phosphorylation of FOXO3a, leading to its translocation from the nucleus to the cytoplasm and preventing its binding to the PRNP promoter