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AKT1 — PRNP
Text-mined interactions from Literome
Liang et al., FEBS J 2009
(Stomach Neoplasms) :
Inhibition of
PrP ( C ) expression by RNA interference
resulted in decreased
p-Akt expression
Seo et al., J Neurochem 2010
(Anoxia...) :
The results indicate that hypoxia protects neuronal cells against PrP ( 106-126 ) -induced cell death by activating the
Akt signal, which is inactivated by prion proteins, and
inhibiting PrP ( 106-126 ) -induced caspase 3 activation
Liu et al., PloS one 2013
:
The activation of
Akt then induces the phosphorylation of FOXO3a, leading to its translocation from the nucleus to the cytoplasm and
preventing its binding to the
PRNP promoter