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CTGF — MYLIP
Text-mined interactions from Literome
Duisters et al., Circ Res 2009
(Disease Models, Animal...) :
miR-133 and miR-30
regulate connective tissue growth factor : implications for a role of microRNAs in myocardial matrix remodeling
Yang et al., Oncogene 2012
(Carcinoma, Squamous Cell...) :
Ectopic
miR-504 increased migration and invasion in
SAS/CTGF-M3 , however, miR-346 did not have such impact on migration/invasion
Xiao et al., Mol Ther 2012
(Disease Models, Animal...) :
Interestingly, overexpression of
miR-29 could in turn negatively
regulated TGF-ß and
connective tissue growth factor (CTGF) expression and Smad3 signaling
Adam et al., Basic Res Cardiol 2012
(Fibrosis) :
A small molecule inhibitor of lysyl oxidase, BAPN, prevented the AngII as well as the
CTGF induced
miR-21 expression
Fox et al., RNA 2013
(Glioblastoma) :
The unexpected
effects of
miR-18a on
CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFß signaling
Lee et al., PloS one 2013
(Brain Neoplasms...) :
In addition
miR-145 regulates glioma cell migration by targeting
CTGF which downregulates SPARC expression
Yu et al., Cell death & disease 2013
(Cell Transformation, Neoplastic...) :
Loss of
connective tissue growth factor as an unfavorable prognosis factor
activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma ... Subsequently, we discovered that the reduction of
CTGF increased the expression of
miR-18b , an oncomir promoting cell proliferation ... Finally, we further found that
miR-18b directly
suppressed the expression of
CTGF in NPC ... Further, we discovered that attenuated
CTGF mediated upregulation of
miR-18b was dependent on the increased binding of transcription factors Jun proto-oncogene (C-Jun) and v-Myc myelocytomatosis viral oncogene homolog ( C-Myc ) to miR-18b promoter region via phosphoinositide 3-kinase (PI3K)/AKT pathway