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AKT3 — FBXO32
Text-mined interactions from Literome
Sandri et al., Cell 2004
(Muscular Atrophy) :
IGF-1 treatment or
AKT overexpression
inhibits Foxo and
atrogin-1 expression
Stitt et al., Mol Cell 2004
(Muscular Atrophy) :
Moreover, the mechanism for this inhibition involves Akt mediated inhibition of the FoxO family of transcription factors ; a mutant form of FOXO1, which prevents Akt phosphorylation, thereby prevents
Akt mediated inhibition of MuRF1 and
MAFbx upregulation
Li et al., J Clin Invest 2007
(Cardiomegaly) :
Our results indicate that
atrogin-1 does not
affect the activity of
Akt itself, but serves as a coactivator for members of the Forkhead family of transcription factors that function downstream of Akt
Zhang et al., Circ Res 2010
(Diabetes Mellitus) :
Moreover, inhibition of
Akt signaling
attenuated the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced
atrogin-1 expression, which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs