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ATF2 — CCND1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., J Biol Chem 1999
(Breast Neoplasms) :
Dominant negative mutants of CREB and
ATF-2 but not c-Jun
inhibited pp60 ( v-src ) induction of
cyclin D1
Sabbah et al., Proc Natl Acad Sci U S A 1999
:
Both c-Jun and
ATF-2 transactivated the
cyclin D1 promoter in transient transfection experiments, and a clear additional increase was detected when ER was cotransfected with either c-Jun or with c-Jun and ATF-2 but not with ATF-2 alone ... To interpret these results, we propose a mechanism in which
ATF-2/c-Jun heterodimers bind to the CRE-D1 element and
mediate the activation of
cyclin D1 promoter by the ER
Castro-Rivera et al., J Biol Chem 2001
(Breast Neoplasms) :
These results contrasted to a recent report showing that induction of
cyclin D1 by E2 in ER-positive MCF-7 and HeLa cells was
due to up-regulation of c-jun and subsequent interaction of
c-Jun-ATF-2 with the CRE
Recio et al., Oncogene 2002
(Melanoma) :
We here report that HGF/SF can induce
cyclin D1 expression in mouse melanoma cells, and that this up-regulation is
mediated in part by the
activating transcription factor-2 ( ATF-2 ) ... However, transcriptional up-regulation of
cyclin D1 by HGF/SF was partially inhibited by the p38 kinase-specific inhibitor, and cyclin D1 protein induction was partially
blocked by a dominant negative
ATF-2 mutant
Lewis et al., J Mol Endocrinol 2005
(Breast Neoplasms) :
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on
cyclin D1 involving the transcription factor
ATF-2 in MCF-7 breast cancer cells
Takasawa et al., FEBS Lett 2006
:
The
Reg/ATF-2 induced
cyclin D1 promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin
Beier et al., Proc Natl Acad Sci U S A 1999
(Chondrosarcoma) :
Overexpression of
ATF-2 in chondrocytes
enhanced activity of the
cyclin D1 promoter 3