Sasaki et al., Jpn J Cancer Res 2001
(Adenocarcinoma...) :
NAC additionally inhibited caspase-3 activity induced by ADM treatment, while Ac-DMQD-CHO showed no suppressive effect on reactive oxygen species ( ROS ) ... Stable antisense-TNF transfectants showed higher ADM sensitivity and greater ADM induced ROS production and caspase-3 activity than mock transfectant or parent cells
DomÃnguez-RodrÃguez et al., Anticancer Res 2004
:
In these experimental conditions, ADM induced AP in a mainly caspase-9 dependent manner and this was related to a reduction in the deltapsim