Raso et al., J Neurochem 1999
(Glioma) :
Prolactin induction of nitric oxide synthase in rat C6 glioma cells
Bolander et al., J Mol Endocrinol 2002
:
Prolactin activation of mammary nitric oxide synthase : molecular mechanisms
Gonzalez et al., Endocrinology 2004
:
In addition, 16K-PRL inhibited eNOS activation by BK and blocked the BK-evoked transient increase in intracellular Ca ( 2+ ) in endothelial cells ... Moreover, 16K-PRL inhibited eNOS activation induced by ACh, and this action resulted in the inhibition of both ACh evoked relaxation of coronary vessels in isolated perfused rat hearts and ACh induced, endothelium dependent relaxation of rat aortic segments ... In conclusion, 16K-PRL can block the Ca ( 2+ ) -mediated activation of eNOS by three different vasoactive substances, and this action results in the inhibition of both angiogenesis and vasorelaxation