Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — DVL3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

González-Sancho et al., Mol Cell Biol 2004 : Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that Dvl phosphorylation is not sufficient to activate canonical Wnt/beta-catenin signaling
Yau et al., Oncogene 2005 (Carcinoma, Hepatocellular...) : Dishevelled ( Dvl ) , a key activator of the pathway, inhibits the adenomatous polyposis coli complex, and this leads to the accumulation of beta-catenin and promotes tumorigenesis
Bryja et al., Cell Signal 2007 : Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of beta-catenin in a PS-Dvl dependent manner
Wei et al., Lung Cancer 2008 (Carcinoma, Non-Small-Cell Lung...) : We also examined the effect of Dvl-1 and Dvl-3 overexpression on beta-catenin expression and the invasive ability of A549 and QG56 lung cancer cells
Gnad et al., Molecular cancer 2010 (Helicobacter Infections) : We analysed the H. pylori induced activation of Wnt signaling factors and demonstrate for the first time that the canonical Wnt signaling proteins LRP6 and Dvl2 and Dvl3 are involved in the regulation of beta-catenin
Zhang et al., Cell Signal 2010 : Among these, Dishevelled ( Dvl ) is a critical regulator that releases beta-catenin from degradation and stabilizes TCF4/beta-catenin complex