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CDC42 — CTNNB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
CDC42/GTP/IQGAP1 complex (CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database N-cadherin signaling events:
RAC1-CDC42/GDP complex (RAC1_CDC42)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Meriane et al., Mol Biol Cell 2000, Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
Reactome Reaction:
CTNNB1
→
CDC42
(indirect_complex)
-
Reactome Reaction:
CTNNB1
→
CDC42
(reaction)
Text-mined interactions from Literome
Fukata et al., J Biol Chem 1999
:
Cdc42 and Rac1
regulate the interaction of IQGAP1 with
beta-catenin ... These results indicate that
Cdc42 and Rac1 negatively
regulate the IQGAP1 function by inhibiting the interaction of IQGAP1 with
beta-catenin , leading to stabilization of the cadherin-catenin complex
Fukata et al., Mol Cell Biol 2001
:
We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin mediated cell-cell adhesion by interacting with
beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and
Cdc42 positively
regulate cadherin mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with beta-catenin
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Paxillin-beta-catenin interactions are involved in
Rac/Cdc42 mediated endothelial barrier-protective response to oxidized phospholipids
Stöffler et al., J Cell Sci 1998
:
This conclusion is based on studies with HtTA-1 HeLa cells that were
induced by overexpression of constitutively active
Cdc42Hs to form typical adherens-type intercellular junctions enriched in cadherins ( N-cadherin ),
beta-catenin , filamentous actin and myr 3