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RPS6KB1 — SREBF1
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Li et al., Zhonghua Gan Zang Bing Za Zhi 2009
(Liver Cirrhosis) :
[
Role of
S6K1 in the induction of
SREBP1c in mouse hepatic cell by high glucose stimulation ] ... To study the
role of
S6K1 in the induction of
SREBP1c in mouse hepatic cell by high glucose stimulation
Li et al., Biochem Biophys Res Commun 2011
(Fatty Liver...) :
Role of
S6K1 in regulation of
SREBP1c expression in the liver ... Furthermore, depletion of hepatic
S6K1 in db/db mice with the use of an adenovirus vector encoding S6K1 shRNA
resulted in down-regulation of
SREBP1c gene expression in the liver as well as a reduced hepatic triglyceride content and serum triglyceride concentration ... These results thus suggest that
S6K1 regulates
SREBP1c expression both in cultured hepatocytes and in mouse liver, and that increased hepatic activity of S6K1 contributes at least in part to the pathogenesis of obesity induced hepatic steatosis and hypertriglyceridemia