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HDAC3 — NCOR1

Pathways - manually collected, often from reviews:

• Reactome Reaction: HDAC3 → NCOR1 (reaction) Gelman et al., J Biol Chem 1999, Farmer et al., Cell Metab 2006, Lambe et al., Eur J Biochem 1996, Lemberger et al., Annu Rev Cell Dev Biol 1996, Mukherjee et al., J Biol Chem 1997
• Reactome Reaction: HDAC3 → NCOR1 (direct_complex) Zhou et al., Mol Cell Biol 2000, Perissi et al., Cell 2004, Yin et al., Mol Endocrinol 2005*, Farmer et al., Cell Metab 2006, Yin et al., Science 2007*, Raghuram et al., Nature structural & molecular biology 2007*, Perissi et al., Mol Cell 2008, Phelan et al., Nature structural & molecular biology 2010*, Oka et al., Development 1995, Lemberger et al., Annu Rev Cell Dev Biol 1996, Kao et al., Genes Dev 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of NCOR1-HDAC1-SIN3A-HDAC3-HDAC2-SAP30 Underhill et al., J Biol Chem 2000
• IRef Bind Interaction: NCOR1 — HDAC3 Yoon et al., EMBO J 2003
• IRef Bind_translation Interaction: NCOR1 — HDAC3 (molecular sieving) Yoon et al., EMBO J 2003
• IRef Bind_translation Interaction: NCOR1 — HDAC3 (coimmunoprecipitation) Yoon et al., EMBO J 2003
• IRef Biogrid Interaction: HDAC3 — NCOR1 (colocalization, biochemical) Yoon et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Zhu et al., Cell 2006
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Bantscheff et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Joshi et al., Molecular systems biology 2013
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Zhang et al., Mol Cell 2002
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Yoon et al., Mol Cell 2003
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Yoon et al., EMBO J 2003
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, pull down) Fischle et al., J Biol Chem 2001
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Fischle et al., Mol Cell 2002
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, two hybrid) Li et al., EMBO J 2000
• IRef Biogrid Interaction: HDAC3 — NCOR1 (colocalization, biochemical) Zhang et al., Mol Cell 2002
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, pull down) Li et al., EMBO J 2000
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Li et al., EMBO J 2000
• IRef Biogrid Interaction: HDAC3 — NCOR1 (association, biochemical) Underhill et al., J Biol Chem 2000
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Alenghat et al., EMBO J 2006*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Wen et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, two hybrid) Jiang et al., Mol Endocrinol 2006*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, pull down) Wen et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (direct interaction, two hybrid) Wen et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (colocalization, imaging technique) Liu et al., J Biol Chem 2004*
• IRef Biogrid Interaction: HDAC3 — NCOR1 (physical association, affinity chromatography technology) Yoon et al., Mol Cell Biol 2005*
• MIPS CORUM NCOR1 complex: NCOR1 complex complex (HDAC3-NCOR1-SF3A1-SF3B3-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SRCAP-TRIM28) Underhill et al., J Biol Chem 2000
• MIPS CORUM NCOR complex: NCOR complex complex (CORO2A-GPS2-HDAC3-NCOR1-TBL1X-TBL1XR1) Yoon et al., EMBO J 2003
• MIPS CORUM NCOR2 complex: NCOR2 complex complex (HDAC1-HDAC2-HDAC3-NCOR1-NCOR2-SAP30-SIN3A) Underhill et al., J Biol Chem 2000
• MIPS CORUM Kaiso-NCOR complex: Kaiso-NCOR complex complex (CORO2A-GPS2-HDAC3-KDM4A-KIF11-NCOR1-TBL1X-TBL1XR1-TRIM33-ZBTB33) Yoon et al., Mol Cell 2003
• MIPS CORUM NCOR-HDAC3 complex: NCOR-HDAC3 complex complex (GPS2-HDAC3-NCOR1-TBL1X-TBL1XR1) Zhang et al., Mol Cell 2002
• IRef Corum Interaction: Complex of 31 proteins (association, molecular sieving) Underhill et al., J Biol Chem 2000
• IRef Corum Interaction: Complex of HDAC3-GPS2-TBL1X-NCOR1-TBL1XR1 (association, anti tag coimmunoprecipitation) Zhang et al., Mol Cell 2002
• IRef Corum Interaction: Complex of 19 proteins (association, mass spectrometry studies of complexes) Yoon et al., EMBO J 2003
• IRef Corum Interaction: Complex of 11 proteins (association, far western blotting) Yoon et al., Mol Cell 2003
• IRef Corum Interaction: Complex of 22 proteins (association, cosedimentation through density gradient) Underhill et al., J Biol Chem 2000
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Yoon et al., EMBO J 2003
• IRef Hprd Interaction: Complex of 31 proteins (in vivo) Alenghat et al., EMBO J 2006*
• IRef Hprd Interaction: Complex of 243 proteins (in vivo) Takezawa et al., EMBO J 2007
• IRef Hprd Interaction: Complex of 51 proteins (in vivo) Zhang et al., Mol Cell 2002
• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Underhill et al., J Biol Chem 2000
• IRef Hprd Interaction: NCOR1 — HDAC3 (in vitro) Li et al., EMBO J 2000, Fischle et al., J Biol Chem 2001, Guenther et al., Mol Cell Biol 2001*, Fischle et al., Mol Cell 2002, Alenghat et al., EMBO J 2006*
• IRef Hprd Interaction: NCOR1 — HDAC3 (two hybrid) Li et al., EMBO J 2000, Fischle et al., J Biol Chem 2001, Guenther et al., Mol Cell Biol 2001*, Fischle et al., Mol Cell 2002, Alenghat et al., EMBO J 2006*
• IRef Hprd Interaction: NCOR1 — HDAC3 (in vivo) Li et al., EMBO J 2000, Fischle et al., J Biol Chem 2001, Guenther et al., Mol Cell Biol 2001*, Fischle et al., Mol Cell 2002, Alenghat et al., EMBO J 2006*
• IRef Hprd Interaction: Complex of 51 proteins (in vivo) Zhang et al., Mol Cell 2002
• IRef Hprd Interaction: Complex of 37 proteins (in vivo) Yoon et al., EMBO J 2003
• IRef Innatedb Interaction: Complex of NCOR1-TAB2-HDAC3 (unknown, -) Baek et al., Cell 2002*
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Jäger et al., Nature 2012
• IRef Intact Interaction: Complex of HDAC3-NCOR1-DDX5 (association, anti tag coimmunoprecipitation) Caretti et al., Dev Cell 2006
• IRef Intact Interaction: Complex of 15 proteins (association, anti tag coimmunoprecipitation) Joshi et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 22 proteins (association, anti tag coimmunoprecipitation) Joshi et al., Molecular systems biology 2013
• IRef Intact Interaction: NCOR1 — HDAC3 (physical association, affinity chromatography technology) Underhill et al., J Biol Chem 2000
• IRef Intact Interaction: Complex of 31 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of KDM1A-NCOR1-TBL1XR1-TBL1X-HDAC3-GPS2 (association, anti bait coimmunoprecipitation) Bantscheff et al., Nat Biotechnol 2011
• IRef Intact Interaction: Complex of NCOR2-ZMYM3-TBL1XR1-HDAC3-GPS2-KDM1A-TBL1X-NCOR1 (association, anti bait coimmunoprecipitation) Bantscheff et al., Nat Biotechnol 2011
• IRef Ophid Interaction: NCOR1 — HDAC3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Herdick et al., J Mol Biol 2000 : This study demonstrates that the interaction of the VDR with NCoR results in a preferential stabilization of the VDR in a non-agonistic conformation ( silent state ), whereas within a complex with SRC-1 VDR is in its agonistic conformation ( activated state )
Wu et al., J Biol Chem 2003 : NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by DACH1 required the DACH1 DS domain ... NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by DACH1 required the DACH1 DS domain ... NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by DACH1 required the DACH1 DS domain
Ishii et al., Mol Endocrinol 2004 (Thyroid Hormone Resistance Syndrome) : TR and NCoR were located on the promoter, and T3 caused NCoR dissociation and steroid receptor coactivator-1 recruitment
Zhang et al., Genes Dev 2005 : Here we demonstrate that, in addition to protein-protein interactions with NCoR/SMRT , the activity of HDAC3 is regulated by both phosphorylation and dephosphorylation
Zhang et al., Mol Cell Biol 2005 : We demonstrated that JMJD2A selectively represses the expression of the ASCL2 gene but not other imprinted genes in the same imprinted locus in HeLa cells and that this repression required a functional N-CoR complex and the tandem Tudor domain of JMJD2A ... We demonstrated that JMJD2A selectively represses the expression of the ASCL2 gene but not other imprinted genes in the same imprinted locus in HeLa cells and that this repression required a functional N-CoR complex and the tandem Tudor domain of JMJD2A
Hatchell et al., Mol Cell 2006 (Breast Neoplasms) : SLIRP is recruited to endogenous promoters ( pS2 and metallothionein ), the latter in a SRA dependent manner, while NCoR promoter recruitment is dependent on SLIRP
Matsuoka et al., Biochem Pharmacol 2007 : Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression ... We therefore focused on the role of HDAC4/N-CoR complex in the transcriptional regulation of IL-2
Furuya et al., Mol Cell Biol 2007 (Thyroid Neoplasms) : Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether NCoR regulates PV-activated PI3K signaling ... Overexpression of NCoR in thyroid tumor cells of TRbetaPV/PV mouse reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT ... Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells led to overactivated p-AKT and increased cell proliferation and motility
Brayman et al., Mol Endocrinol 2007 (Breast Neoplasms) : Overexpression of PIASy did not affect P receptor B binding to the MUC1 promoter but surprisingly led to a loss of nuclear receptor corepressor (NCoR) , which was recruited to the promoter in response to P. Collectively, these data indicate that PIASy may be a useful target for down-regulation of MUC1 expression in various contexts
Sundaram et al., J Cell Biochem 2008 : Co-expression of NCoR with DACH1 significantly decreased ( 5.3-fold ) and siRNA suppression of NCoR in DACH1 co-transfected cells increased ( 3.6-fold ) RANKL promoter activity ... Co-expression of NCoR with DACH1 significantly decreased ( 5.3-fold ) and siRNA suppression of NCoR in DACH1 co-transfected cells increased ( 3.6-fold ) RANKL promoter activity
Higgins et al., Mol Endocrinol 2008 : This study illustrates that both SMRT and NCoR are involved in E2-dependent repression of VEGFR2 in MCF-7 cells
Song et al., J Biol Chem 2008 : Overexpression of SMRT and NCoR attenuated the transcription of beta-catenin-TCF4-specific reporter gene and of CCND1, an endogenous beta-catenin target gene ... Overexpression of SMRT and NCoR attenuated the transcription of beta-catenin-TCF4-specific reporter gene and of CCND1 , an endogenous beta-catenin target gene ... Overexpression of SMRT and NCoR attenuated the transcription of beta-catenin-TCF4-specific reporter gene and of CCND1, an endogenous beta-catenin target gene
Jennewein et al., J Immunol 2008 : Chromatin immunoprecipitation analysis demonstrated that AC prevented the LPS induced removal of nuclear receptor corepressor (NCoR) from the kappaB site within the TNF-alpha promoter
Furuya et al., Steroids 2009 (Thyroid Neoplasms) : Over-expression of NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice reduces AKT-mTOR-p70 ( S6K ) signaling ... Over-expression of NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice reduces AKT-mTOR-p70 ( S6K ) signaling ... Over-expression of NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over activated PI3K-AKT signaling to increase cell proliferation and motility ... Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over activated PI3K-AKT signaling to increase cell proliferation and motility
Alenghat et al., Nature 2008 (Obesity) : These findings indicate that activation of Hdac3 by Ncor1 is a nodal point in the epigenetic regulation of circadian and metabolic physiology
Zhang et al., J Biol Chem 2009 : DBC1 stabilized the interaction between COUP-TFI and NCoR by interacting directly with both proteins
Wang et al., Mol Endocrinol 2009 : These findings demonstrate the critical role of NCoR/HDAC3 complex in negative regulation of TSHalpha gene expression and show that similar complexes and overlapping epigenetic modifications can participate in both negative and positive transcriptional regulation
Hodgson et al., Cancer Res 2011 (Neoplasm Recurrence, Local...) : Optimal induction of INPP4B by an androgen receptor required the expression of the transcriptional coactivator NCoR ... Optimal induction of INPP4B by an androgen receptor required the expression of the transcriptional coactivator NCoR
Portal et al., Proc Natl Acad Sci U S A 2011 (Cell Transformation, Viral) : These data strongly support a model in which EBNA2 association with NCoR-deficient RBPJ enhances transcription and EBNALP dismisses NCoR and RBPJ repressive complexes from enhancers to coactivate hes1 and arglu1 but not cd21 or cd23
Finlin et al., Metab Syndr Relat Disord 2012 : Small interfering RNA ( siRNA ) -mediated knockdown of SUMO-1 decreased PPAR?, HDAC3, and NCoR in THP-1 cells and increased tumor necrosis factor-a (TNF-a) induction in response to lipopolysaccharide (LPS)
Liu et al., J Biol Chem 2012 : SUMO1 was required for the T3-induced recruitment of the co-activator CREB binding protein (CBP) and release of nuclear receptor co-repressor (NCoR) on a TRE but had no significant effect on TR DNA binding
Choi et al., J Cell Physiol 2013 (Prostatic Neoplasms) : We demonstrated that the Serine-70 of NCoR is identified the critical amino acid for PKA dependent NCoR phosphorylation ... More importantly, the activation of PKA enhanced the repressive activity of NCoR in a reporter assay and potentiated the antagonist activity in the Androgen Receptor (AR) mediated transcription
Lit et al., Anticancer Res 2013 (Breast Neoplasms...) : At the protein level, inhibition of LATS2 reduces the expression of cyclin-D1 and Nuclear Receptor Co-Repressor (NCoR) while increasing the expression of p27