Fan et al., Acta Pharmacol Sin 2007
:
Resistin also diminished insulin stimulated IRS-1 tyrosine phosphorylation levels without affecting its protein content
Benomar et al., Diabetes 2013
(Insulin Resistance) :
Additionally, central resistin promotes the activation of the serine kinases Jun NH ( 2 ) -terminal kinase and p38 mitogen activated protein kinase, enhances the serine phosphorylation of insulin receptor substrate-1 , and increases the expression of the proinflammatory cytokine interleukin-6 in the hypothalamus and key peripheral insulin-sensitive tissues