Gene interactions and pathways from curated databases and text-mining

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EPHB2 — PARP8

Text-mined interactions from Literome

Weiderhold et al., Int J Cancer 2006 (Mammary Neoplasms, Animal) : Bcl-2 phosphorylation and activation of ERK and JNK and caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694
Lee et al., J Neurochem 2009 (Neuroblastoma) : Furthermore, inhibition of ERK reduced ONE induced phosphorylation of p53, a key modulator of the cellular stress response, and the proteolytic cleavage of poly ( ADP-ribose ) polymerase ( PARP ), a hallmark of apoptosis
Gatson et al., Journal of neuroinflammation 2009 (Burns...) : In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Zeng et al., J Ethnopharmacol 2010 : In addition, MWG extract attenuated activation of caspase-3 and poly ADP-ribose polymerase ( PARP ) and inhibited the phosphorylation of ERK , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs