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Interleukin (IL)-1beta ( 25 ng/ml ), IL-8 ( 25 ng/ml ), growth related oncogene-alpha ( GRO, 50 ng/ml ) and tumor necrosis factor-alpha ( TNF-alpha, 25 ng/ml ) stimulated the COX-1 protein production as demonstrated by Western blot and enhanced PGE2 synthesis in GMC, beginning on 2 h of incubation, and steadily enhanced TXB2 synthesis over a 24-h period
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The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation