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FOSL1 — MAPK8
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Balmanno et al., Oncogene 1999
:
The expression of c-Fos,
Fra-1 and JunB was
dependent upon the activation of
MAPK since these responses were inhibited by PD098059 ... However, a comparison of responses to FBS, thrombin, TRPs, LPA and EGF revealed that
Fra-1 and JunB expression
required sustained activation of
MAPK whereas c-Fos expression was strongly induced even by non-mitogenic stimuli which elicited only transient MAPK activation
Hurd et al., Biochem J 2002
:
Dual
role for
mitogen activated protein kinase ( Erk ) in insulin dependent regulation of
Fra-1 ( fos related antigen-1 ) transcription and phosphorylation
Cook et al., Mol Cell Biol 1999
:
In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of
Raf-MEK-MAPK was
sufficient to induce expression of
Fra-1 , Fra-2, and JunB but, interestingly, induced little or no c-Fos or c-Jun ... These results suggest that kinetically distinct phases of MAPK activation serve to regulate the expression of distinct AP-1 components such that sustained
MAPK activation is
required for the induced expression of
Fra-1 , Fra-2, c-Jun, and JunB