Gene interactions and pathways from curated databases and text-mining

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CD4 — TNFSF10

Text-mined interactions from Literome

Tsai et al., Arthritis Rheum 2004 (Lupus Erythematosus, Systemic) : TRAIL engagement selectively activated human CD4 , rather than CD8, T cells and augmented IFNgamma production
Bosque et al., Eur J Immunol 2005 : Additionally, the inhibition of IL-2 dependent CD4 ( + ) or CD8 ( + ) T cell blast growth upon CD3 or CD59 ligation was dependent , at least partially, on FasL and/or APO2L/TRAIL
Lum et al., AIDS 2005 (HIV Infections) : The increase in TRAIL death receptor expression and acquisition of TRAIL sensitivity requires the chemokine coreceptor CXCR4 but not CCR5 or the CD4 receptor
Herbeuval et al., AIDS Rev 2006 (HIV Infections) : However, soluble CD4 ( sCD4-IgG ) efficiently blocked IFNalpha production, TRAIL and DR5 expression and apoptosis of T helper cells
Wang et al., Endocrinology 2009 (Disease Models, Animal...) : In the present study, we specifically examined TRAIL effects on CD4 ( + ) CD25 ( + ) regulatory T cells