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APC — CD4

Text-mined interactions from Literome

Dembic et al., Proc Natl Acad Sci U S A 2000 (Multiple Myeloma) : The APC could stimulate Id-specific naive TCR-TG, short-term polarized TCR-TG, and cloned CD4 ( + ) T cells to proliferate and produce cytokines in vitro
Richards et al., Eur J Immunol 2000 : This study demonstrates, more critically, that when APC are present, glucocorticoids induce CD4 and CD8 T cell populations synthesizing high levels of IL-10, but greatly reduced amounts of disease promoting IL-4 and IL-5
Qi et al., J Immunol 2000 (Sarcoma, Experimental) : Because class II ( + ) tumor cells are effective APC in vivo and probably present novel tumor Ag epitopes not presented by host derived APC, their inclusion in cancer vaccines may enhance activation of tumor-reactive CD4 ( + ) T cells
Suciu-Foca et al., Transpl Immunol 2003 : Tolerized APC , which expresses high ILT3 and ILT4, trigger the generation of antigen-specific CD4 ( + ) T ( R ) propagating antigen-specific suppression
Parker et al., Transplantation 1992 : In vitro proliferation studies demonstrated that CD4+ but not CD8+ T cells of the PVG strain responded in a recipient APC dependent manner to the peptide, whereas the BN strain ( which showed no antibody response to this peptide ) gave no T cell proliferation
Gelman et al., J Immunol 2004 : APC TLR engagement indirectly enhances activated CD4 ( + ) T cell proliferation, differentiation, and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines
Fazal et al., Biochim Biophys Acta 2006 (Burns...) : This altered APC : CD4+ T cell interaction leads to suppressed CD4+ T cell activation of healthy animals
Chang et al., Cytotherapy 2007 (Glioma...) : Background The role of co-stimulation in CD4+ T cell activation by professional APC is well established, while less is known of the role co-stimulation plays when CD4+ T cells interact directly with tumor cells
Manirarora et al., PloS one 2008 (Diabetes Mellitus) : APC activation restores functional CD4 ( + ) CD25 ( + ) regulatory T cells in NOD mice that can prevent diabetes development
Moran et al., Inflamm Bowel Dis 2009 (Bifidobacteriales Infections...) : Bacterial antigen-specific CD4 ( + ) mesenteric lymph node (MLN) T-cell recall responses were measured in response to antigen presenting cells (APC) pulsed with bacterial lysates
Shih et al., Eur J Immunol 2009 (Inflammatory Bowel Diseases) : Microbial induction of TL1A production by human APC potentiated CD4 ( + ) T-cell effector function by augmenting IFN-gamma production
Schiechl et al., Am J Transplant 2013 (Disease Models, Animal) : We examined the effect of TREM-1 ( + ) antigen presenting cells (APC) on alloreactive CD4 ( + ) lymphocytes
Schnyder et al., J Clin Invest 1997 (Cell Transformation, Viral...) : The stimulation of four CD4 ( + ) and two CD8 ( + ) sulfamethoxazole-specific T cell clones by different antigen presenting cells (APC) was measured both by proliferation and cytolytic assays
Mannie et al., Cell Immunol 1998 : In this study, single positive CD4+ and double negative ( DN ) ( CD4-CD8- ) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig ( GP ) myelin basic protein ( GPMBP ) were used to study CD4 regulation of T-APC activity