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LPA — SMN1
Text-mined interactions from Literome
Jeon et al., Stem Cells 2008
(Ascites...) :
The
LPA induced expression of
alpha-SMA was completely abrogated by pretreatment of the cells with Ki16425, an antagonist of LPA receptors, or by silencing LPA ( 1 ) or LPA ( 2 ) isoform expression with small interference RNA ( siRNA ) ... LPA elicited phosphorylation of Smad2/3, and siRNA mediated depletion of endogenous Smad2/3 or adenoviral expression of Smad7, an inhibitory Smad, abrogated the
LPA induced expression of
alpha-SMA and phosphorylation of Smad2/3 ... LPA induced secretion of transforming growth factor (TGF)-beta1 in hADSCs, and pretreatment of the cells with SB431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody inhibited the
LPA induced expression of
alpha-SMA and phosphorylation of Smad2
Jeon et al., Exp Mol Med 2010
(Ovarian Neoplasms) :
LPA activated RhoA in hASCs and pretreatment with the Rho kinase inhibitor Y27632 completely abrogated the
LPA induced expression of
alpha-SMA , SDF-1, and VEGF in hASCs ... Moreover,
LPA induced
alpha-SMA expression was abrogated by treatment with the ERK inhibitor U0126 or the phosphoinositide-3-kinase inhibitor LY294002, but not the PLC inhibitor U73122
Heo et al., Biochim Biophys Acta 2011
(Adenocarcinoma...) :
Small interfering RNA- or short hairpin RNA mediated silencing of periostin resulted in blockade of
LPA induced
a-SMA expression in hASCs