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BMP2 — SOX9

Text-mined interactions from Literome

Zehentner et al., J Bone Miner Res 1999 : The transcription factor Sox9 is involved in BMP-2 signaling ... We investigated the regulation of Sox9 , a transcription factor known to play a role in chondrogenesis, by bone morphogenetic protein-2 (BMP-2) and hedgehog proteins in order to better understand their signaling function in endochondral bone formation ... We found that Sox9 was up-regulated by BMP-2 in a dose dependent manner
Zehentner et al., Dev Growth Differ 2002 : BMP-2 caused significant upregulation of Sox9 and Noggin expression in these cells
Zeng et al., Genes Dev 2002 : We have found that in the presence of BMP signals, Sox9 and Nkx3.2 induce each other 's expression
Theodosiou et al., Dev Biol 2005 : Despite these similarities, our evidence suggests that Sox9 and Nkx2.5 are regulated independently by BMP signaling, and act coordinately to specify the pyloric sphincter
Sakai et al., Development 2006 : In this study, our gain-of-function and loss-of-function experiments reveal that Sox9 is essential for BMP signal mediated induction of Snail2 and subsequent EMT in avian neural crest
Jin et al., Mol Cells 2006 : In agreement with this, the interaction of Sox9 with b-catenin was inhibited in the presence of BMP-2
Pan et al., J Cell Physiol 2008 : In the MEFs, BMP-2 efficiently induced Sox9 expression along with chondrogenic differentiation in a time- and dose dependent manner ... SB203580, a specific inhibitor for p38 pathway, blocked BMP-2 induced chondrogenic differentiation as well as Sox9 expression and its transactivation of downstream genes ... This study provides insight into the mechanisms underlying BMP-2 regulated Sox9 expression and activity in MEFs, and suggests differential roles of BMP-2/p38 and BMP-2/Smad pathways in modulating the function of Sox9 during chondrogenesis
Pan et al., Biochem Biophys Res Commun 2009 : Collectively, these data suggest that the activation of Sox9 gene transcription by BMP-2 is associated with chromatin remodeling and histone modification
Nakanishi et al., Biochem Biophys Res Commun 2009 (Chondromatosis, Synovial) : BMP-2 stimulated the expression of Sox9 , Col2a1, and Aggrecan mRNAs in free-body and synovial cells and that of Runx2, Col1a1, and Osteocalcin mRNAs in the synovial [ corrected ] cells only
Smith et al., J Orthop Res 2011 (Osteoarthritis, Knee) : Articular chondrocytes, isolated from femoral OA cartilage and maintained in high-density monolayer culture, were examined for effects of BMP-2 and IHP on gene expression of matrix associated proteins ( aggrecan, type II collagen, and SOX9 ) and catabolic matrix metalloproteinases ( MMP-2 and MMP-3 ) and culture medium levels of the metabolic markers MMP-2, nitric oxide ( NO ), and glycosaminoglycan ( GAG ) ... Type II collagen and SOX9 gene expression were stimulated by both IHP and BMP-2 whereas aggrecan was increased only by BMP-2