Koide et al., Biochem Biophys Res Commun 1999
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It is noted that BMP-2 alone did cause an increase in the expression of both COX-2 and ODF genes ... Since BMP-2 alone induced the expression of COX-2 and ODF genes in osteoblast-like cells, it appears to be one of the regulating factors of osteoclastogenesis
Chikazu et al., J Bone Miner Res 2002
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Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site : role in effects of bone morphogenetic protein 2 in vitro and in vivo ... In cultured osteoblasts from calvariae of COX-2 knockout ( -/- ) and wild-type ( +/+ ) mice, the absence of COX-2 expression reduced the BMP-2 stimulation of both ALP activity and osteocalcin mRNA expression ... We conclude that BMP-2 transcriptionally induces COX-2 in osteoblasts via a Cbfal binding site and that the BMP-2 induction of COX-2 can contribute to effects of BMP-2 on osteoblastic differentiation and osteoclast formation in vitro and to the BMP-2 stimulation of ectopic bone formation in vivo
Bradley et al., J Periodontal Res 2007
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Cyclooxygenase-2 inhibitor reduces simvastatin induced bone morphogenetic protein-2 and bone formation in vivo