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CXCL12 — RAC2
Text-mined interactions from Literome
Takesono et al., Curr Biol 2004
:
Expression of a dominant negative Itk impaired
SDF-1alpha induced migration, cell polarization, and activation of
Rac and Cdc42
GarcĂa-Bernal et al., Mol Biol Cell 2005
:
CXCL12 activates the GTPase
Rac , as well as Vav1, a guanine-nucleotide exchange factor for Rac, concomitant with up-regulation of alpha4beta1 dependent adhesion ... Importantly, inhibition of Vav1 expression by RNA interference resulted in a blockade of
Rac activation in
response to
CXCL12 ... Adhesions in flow chambers and soluble binding assays using these transfectants indicated that initial ligand binding and adhesion strengthening mediated by alpha4beta1 were dependent on Vav1 and
Rac activation by
CXCL12
Bartolomé et al., Cancer Res 2006
(Melanoma...) :
Blocking Vav expression by RNA interference results in impaired
activation of
Rac and Rho by
CXCL12 and in a remarkable inhibition of CXCL12 promoted invasion
Tan et al., J Biol Chem 2006
(Neoplasm Metastasis) :
We observed that whereas G ( i ) and Gbetagamma subunits are involved in
SDF-1 induced
Rac activation and cell migration, CXCR4 can also stimulate Rho potently leading to the phosphorylation of myosin light chain through the Rho effector, Rho kinase, but independently of G ( i )
Fuhler et al., Blood 2008
(MAP Kinase Signaling System...) :
Furthermore,
SDF-1 stimulated activation of
Rac and the PI3K target protein kinase B is impaired in CD34 ( + ) cells from MDS patients ... In addition, expression of constitutive active
Rac increases the motility of MDS CD34 ( + ) cells in the absence of
SDF-1 , although the directional migration of cells toward this chemoattractant is not affected
Sai et al., J Biol Chem 2008
:
Parallel phosphatidylinositol 3-kinase (PI3K) dependent and Src dependent pathways lead to
CXCL8 mediated
Rac2 activation and chemotaxis